Abstract
To elucidate the inhibitory action of acetogenins, the most potent inhibitors of mitochondrial complex I, we synthesized an acetogenin analogue which possesses a ubiquinone ring (i.e., the physiological substrate of complex I) in place of the alpha,beta-unsaturated gamma-lactone ring of natural acetogenins, and named it Q-acetogenin. Our results indicate that the gamma-lactone ring of acetogenins is completely substitutable with the ubiquinone ring. This fact is discussed in light of the inhibitory action of acetogenins.
MeSH terms
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Acetogenins
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Animals
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Cattle
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Electron Transport Complex I / antagonists & inhibitors*
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Furans / chemical synthesis*
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Furans / pharmacology*
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Indicators and Reagents
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Mitochondria, Heart / drug effects
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Mitochondria, Heart / metabolism
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NADH, NADPH Oxidoreductases / antagonists & inhibitors
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NADH, NADPH Oxidoreductases / metabolism
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Ubiquinone / analogs & derivatives
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Ubiquinone / chemical synthesis*
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Ubiquinone / pharmacology*
Substances
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Acetogenins
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Furans
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Indicators and Reagents
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Q-acetogenin
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Ubiquinone
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NADH, NADPH Oxidoreductases
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Electron Transport Complex I